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Retinoids - Treatment using Retinoid Therapy

Vitamin A, which is also called retinol, is a yellow, fat-soluble vitamin compound found in egg yolk, butter, carrots and other vegetables. It is one of the vital and essential vitamins that helps develop and maintain normal skin. Vitamin A is referred to as a normalizer that could reverse skin abnormalities including pre-cancerous cells. In addition, vitamin A is one of the most powerful anti-oxidants. Vitamin A has quite a few derivatives such as retinyl acetate, propionate, palmitate, etc. These derivatives are usually more stable than vitamin A with similar benefits to the skin. Both vitamin A and its derivatives have a distinct yellow color and are called retinoid in chemistry.

All retinoid are oil soluble and are lipophilic. Due to its weak stability, very limited retinoid products are on the market. Even so, their strength is very low.

There are many brand name face creams that contain retinol or retinaldehyde, which may help improve the appearance of aging skin.

Retinoid Treatments

Retinoid Treatments are usually performed after a general facial treatment such as a facial mask or facial massage. They generally can irritate the skin and increase the chance of sunburn. Excessive use may result in redness and peeling.

Retinoid therapy in neuroblastoma

Moreover, a clinical trial has demonstrated a role for a derivative of retinoid in the therapy of children with advanced neuroblastoma. We have focused much of our work on identifying molecules necessary for the retinoid anti-cancer effect in neuroblastoma cells, and on investigating the phenomenon of resistance to retinoic acid in cancer cells.

What is the Fetal Retinoid Syndrome?

Fetal retinoid syndrome is a characteristic pattern of physical and mental birth defects that results from a mother's use of retinoid during pregnancy, usually during the first three months. A mucous membrane one type of thin sheets of tissue that line or cover various parts of the body. Retinoid are medication made of artificial forms of vitamin A. Vitamin A is very important for healthy eyes, skin, hair, and mucous membranes.

Overcoming retinoid resistance

Resistance to retinoid treatment for cancer is partly due to a reduced transcriptional response (a lower level of gene expression) of target genes to retinoid. We have found specific mechanisms by which the genes necessary for retinoid anticancer signaling are 'switched off' in retinoid-resistant cells, and have been able to reverse the effects.



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